Mikhail Krasavin

HONORARY DEGREES AND CHAIRS

Feb 2016

elected Professor of the Russian Academy of Sciences (the RAS Profesor) ^RU

DEGREES AND TRAINING

11/2011	Defended (24.05.2011) a DSc (Habilitation) Dissertation «New Synthetic Strategies Involving Isocyanide-Based Multicomponent Reactions». The respective degree in Organic Chemistry was conferred by the Higher Attestation Committee of the Russian Federation on 18.11.2011
12/2006	Defended (06.12.2006) a PhD Dissertation «Design, Synthesis and Biological Activity of 1,2,4-Trioxane Analogs of Artemisinin» in Organic Chemistry at the Gubkin Gas & Oil University of Russia (Moscow)
05/1999	Master of Arts in Organic/Medicinal Chemistry (under Prof Gary H. Posner) from The Johns Hopkins University (Baltimore, MD)
06/1997	Visiting Diploma student at Organic Chemistry Dept, Lund University (Sweden)
01/1997	Completed undergraduate chemistry training with concentration in Physical Organic Chemistry (St. Petersburg State University, Russia)
May 19-23rd, 2003	Pharmaceutical Industry Short Course in Pharmacology (U Wisconsin, Madison)
01-10/2009	Advanced training course in Natural Science Teaching Methodology (The Ushinsky State Pedagogical University, Yaroslavl, Russia)

POSITIONS

2014 – present	Professor of Organic Chemistry, St. Petersburg State University (Russia) Teaching and supervision of an independent research group. Multiple collaborations in the field of medicinal chemistry and drug discovery across the Globe. Recipient of a 2014-2018 Russian Scientific Fund institutional grant (along with four other recipients) «Translational biomedicine at SPbSU», aimed at establishing a chemical pharmacology laboratory within the University.
2011 – 2013	Group Leader and Institute Member, Eskitis Institute for Drug Discovery, Griffith University (Brisbane, QLD, Australia) Ran an independent research group in synthetic and medicinal chemistry (2 PhD students, 1 Master student, 1 postdoc) Attracted external grant funding (AU$115,000 from Griffith University in 2012-2013, AU$395,000 from Australian Research Council in 2013) Served as the Chairman of the Queensland Compound Library Management Committee, the only Australian resource providing compounds for biological screening Liaised closely with the State and Federal governments on QCL funding Attracted AU$2.5M in Federal funding for expanding the QCL’s infrastructure Selected and purchased a diverse library of 34,000 new drug-like compounds from 11 major compound vendors worldwide Built effective collaborations with research groups in U California, Aristotle University in Greece, U Alberta in Canada, U Sydney, U Melbourne, U Western Australia aimed at biological profiling of the new compounds designed and synthesized in my group Building industry collaborations (Eli Lilly and Co., Merck KGaA) in the area of Open Innovation in drug discovery
2007 – 2011	Head of Medicinal Chemistry, Chemical Diversity Research Institute (Khimki, Moscow) Ran project groups of 4-20 researchers in preclinical drug discovery research in such therapeutic areas as oncology, metabolic disease, central nervous system disease for such key pharma and biotech clients as Abbott Laboratories, Solvay Pharmaceuticals, Nerviano Medical Sciences Identified and optimized (with respect to the target biological activity, ADMET profile and off-target profile over 20 lead series, some of which reached a clinical candidate status Advanced one chemical series (see patents with Nerviano Medical Sciences) to the clinicalcandidate status in oncology Extensive off-site meetings to develop new proposals, project structure, evaluate project costs and develop milestone criteria Maintained regular detailed and time-bound reporting on the projects, met with the clients face-to-face to discuss research progress and develop solutions to emerging hurdles Analyzed biological data and made decisions on advancement or discontinuation of particular biologically active chemical series Interacted closely with cross-functional teams including compound management, logistics, computational chemistry, high-throughput screening, in vitro and in vivo pharmacology Outsourced parts of project work to academic and industry partners
2007	Postdoctoral fellow, Dept of Chemistry, McGill University (Montreal, Quebec) Short-term research visit to Ass. Prof. Marcus Lindström's group to work on enantioselective catalysis in water Joint publication in Eur. J. Org. Chem.
2004 – 2007	Associate Director for Custom Chemistry, Chemical Diversity Research Institute (Khimki, Moscow) Built a custom synthesis program from scratch to accommodate strong partnering demand from key pharma and biotechnology clients Ran project teams of 5-35 chemists Successfully closed >$10M in synthesis contracts for such clients as Eli Lilly and Co., Merck KGaA, Sanofi Aventis, GSK, Takeda Pharmaceutical Co., Bayer-Schering and others Traveled extensively for client meetings to develop new proposals, project structure, evaluate project costs and develop milestone criteria Maintained regular detailed and time-bound reporting on the projects, met with the clients face-to-face to discuss research progress and develop solutions to emerging hurdles
2002 – 2003	Senior Research Associate, Medicinal Chemistry, Abbott Bioresearch Center (Worcester, MA)
2000 – 2001	Senior Research Associate, Medicinal Chemistry, Millennium Pharmaceuticals, Inc. (Cambridge, MA) Conducted laboratory research in synthetic organic and medicinal chemistry to support preclinical discovery programs in immunology and oncology (targets – kinases, GPCRs) Wrote regular research reports, submitted compounds for biological profiling, interacted with the biology and crystallography teams to define path for further optimization of active chemical series
1997 – 1999	Graduate research associate and Teaching assistant, The Johns Hopkins University (Baltimore, MD) Led section seminars in organic chemistry for sophomore and junior chemistry and pre-med students Graded exams Laboratory research to synthesize and study biologically active analogs of an antimalarial natural product Responsible for compounds' testing at the JHU School of Medicine

CONCOMITANT SCIENTIFIC POSTS

Head, Laboratory of Chemical Pharmacology, Institute for Translational Biomedicine, St Petersburg State University (ITBM SPbSU).
Research Professor, Life Science Institute, Immunuel Kant Baltic Federal University.

CONSULTANCY

BIOCAD (St. Petersburg, Russia)
Werteks (St. Petersburg, Russia)

TEACHING EXPERIENCE

St. Petersburg State University: Medicinal Chemistry for Graduate Students in Organic Chemistry.
Johns Hopkins University: Introductory and Intermediate Organic Chemistry.

PROFESSIONAL SOCIETY MEMBERSHIPS

Russian Chemical Society (since 2017)
Society for Biomolecular Screening (since 2009)
American Chemical Society (since 1999)

REVIEWER ACTIVITY

ACS Combinatorial Science, ACS Medicinal Chemistry Letters, Anti-Infective Agents, Arabian Journal of Chemistry, Archiv der Pharmazie, Asian Journal of Organic Chemistry, Beilstein Journal of Organic Chemistry, Bioorganic and Medicinal Chemistry Letters, Chemistry of Heterocyclic Compounds, Chemistry of Heterocyclic Compounds, Current Enzyme Inhibition, European Journal of Medicinal Chemistry, Journal of Combinatorial Chemistry, Journal of Enzyme Inhibition and Medicinal Chemistry, Journal of Medicinal Chemistry, Journal of Organic Chemistry, Medicinal Chemistry, Molecular Diversity, Monatshefte für Chemie, Organic Letters, Synthetic Communications, Tetrahedron, Tetrahedron Letters.
Expert of the Russian Academy of Sciences (RAS Expert ID 2016-01-2672-2250).
Ad hoc manuscript reviewing for: Tetrahedron Letters, Molecular Diversity, Archiv der Pharmazie, Synthetic Communications, Monatshefte für Chemie, Journal of Organic Chemistry, Journal of Combinatorial Chemistry, ACS Combinatorial Science, Chemistry of Heterocyclic Compounds, Bioorganic and Medicinal Chemistry Letters, Beilstein Journal of Organic Chemistry, Anti-Infective Agents, Medicinal Chemistry, Journal of Enzyme Inhibition and Medicinal Chemistry, ACS Medicinal Chemistry Letters, Current Enzyme Inhibition, Arabian Journal of Chemistry, Asian Journal of Organic Chemistry.
Grant assessor for Australian Research Council 2012-2013.
Recognized by Elsevier Publishers as one of the ten best reviewers in 2015 for Tetrahedron journals.
Expert reviewer for the Russian Science Foundation (RSF) and Russian Foundation for Basic Research.

EDITORIAL ACTIVITY

Editorial Board Member of "Letters in Organic Chemistry" journal (Bentham Science)
Editorial Board Member of "Molecules" journal (MDPI)
Editorial Board Member of "Journal of Enzyme Inhibition and Medicinal Chemistry" (Taylor & Francis)

THESIS SUPERVISION

8 PhD Theses defended under my supervision
Supervised parts of PhD work of two graduate students at Griffith University: Dr. Prashant Mujumdar (2017) and Dr. Pakornwit Sarnpitak (2017)
Currently supervising 3 PhD students at Saint Petersburg State University

COMMITTEE POSITIONS

Chairman of the Queensland Compound Library (Compounds Australia) Management Committee, the only Australian resource providing compounds for biological screening.
Served on Therapeutic Innovations Australia board (resource area – Screening).
Post-doctoral research associate selection committee, Griffith University.
Member of the Scientific Council on Medicinal Chemistry of the Chemistry and Material Science Branch of the Russian Academy of Sciences.

SPEAKING ENGAGEMENTS

MIKHAIL KRASAVIN SPEAKING ENGAGEMENTS

RESEARCH AND INFRASTRUCTURE FUNDING

Sci-o-metrics

H-index — 26 (Web of Science)

H-index — 28 (Scopus)

H-index — 31 (Google Scholar)